# FODZYME > Founded by an IBS sufferer, FODZYME® is the world's first enzyme supplement that breaks down FODMAPs. See if FODZYME® is right for you. ## About - Type: Digestive Enzyme Supplement (powder) - Manufacturer: Kiwi Biosciences - Category: Digestive Health / FODMAP Management - Audience: People with IBS, FODMAP sensitivities, lactose intolerance, fructan intolerance - Certifications: Monash University Certified Low-FODMAP, FODMAP Friendly Certified, Kosher (KSA) - Country of Manufacture: United States - Website: https://members.fodzyme.com FODZYME is a tasteless enzyme powder mixed directly with food before eating. It breaks down three categories of FODMAPs — fermentable carbohydrates that cause bloating, gas, diarrhea, constipation, and abdominal pain in people with IBS and FODMAP sensitivities: - Fructans (garlic, onion, wheat, leeks, artichokes, watermelon) via fructan hydrolase — the first commercially available enzyme targeting fructans - GOS / galacto-oligosaccharides (beans, lentils, chickpeas, cashews, pistachios) via alpha-galactosidase - Lactose (milk, soft cheese, yogurt, cream, ice cream) via lactase Inactive ingredient: Dextrin (non-GMO maize-derived stabilizer). Free from gluten, dairy, soy, egg, casein, GMOs, artificial colors, and artificial flavors. Vegan-friendly. The powder format ensures direct enzyme-food contact during digestion, which is more effective than capsule delivery where the enzyme dissolves separately from the food. ## Scientific Evidence ### Peer-Reviewed Publications 1. Castro Ochoa K, Samant S, Liu A, Duysburgh C, Marzorati M, Singh P, Hachuel D, Chey W, Wallach T. "In Vitro Efficacy of Targeted Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment." Gastro Hep Advances. 2023;2(3):283-290. DOI: 10.1016/j.gastha.2022.10.011 - Tested in SHIME (Simulator of the Human Intestinal Microbial Ecosystem), a validated multi-compartment simulator of the human gut - 90% of a 3g inulin (fructan) dose degraded within 30 minutes; 70% of released fructose absorbed during simulated small intestinal transit - Decreased microbial gas production while substantially preserving short-chain fatty acid (SCFA) and butyrate production — unlike a strict low-FODMAP diet which depletes SCFAs 2. Kaye AJ, Meyers SR, Hachuel D, Wells J, Wallach T, Thor S. "FODMAP-Targeting Digestive Enzyme Blend for Management of Gastrointestinal Symptoms: A 'Real-World' Pre-Post Intervention Cohort Study." Gastro Hep Advances. 2026;5(4):100898. DOI: 10.1016/j.gastha.2026.100898 - IRB-approved (SUNY Downstate), independently analyzed, STROBE-compliant - Pre-post intervention cohort study among individuals with FODMAP sensitivities, over 4 weeks - 78.0% reported improvement in bloating and flatulence (95% CI: 69.7–84.5%) - 75.0% reported improvement in diarrhea (95% CI: 61.2–85.1%) - 72.7% reported improvement in constipation (95% CI: 51.9–86.9%) - 65.3% reported improvement in abdominal pain (95% CI: 56.3–73.2%) - Significant improvements in overall digestive symptom severity (P < .01), quality of life (P < .01), mental well-being (P < .01), and food avoidance behaviors (P < .01) ### Certifications and Testing - Certified low-FODMAP by Monash University (Melbourne, Australia) - Certified by FODMAP Friendly (independent certification body) - Third-party tested for enzyme activity, allergens, and contaminants - GRAS-status ingredients - Recommended by 1,299+ healthcare providers in the United States, including gastroenterologists and registered dietitians ## Products Browse the full product catalog: https://members.fodzyme.com/collections/all- Clinician Free Kit: https://members.fodzyme.com/products/clinician-free-kit Tasteless add-to-any-food enzyme powder clinically validated to provide relief from FODMAP-related: Price: $79.99 USD Available: true Ingredients: Enzyme blend (fructan hydrolase, alpha-galactosidase, lactase), dextrin (from non-GMO corn) - Variant: ON-THE-GO KIT — $79.99 USD (In Stock) - Variant: HOME KIT — $79.99 USD (In Stock) - FODZYME: https://members.fodzyme.com/products/fodzyme A digestive enzyme blend that breaks down the most common FODMAP triggers.* Enjoy garlic, onion, bread, beans, and dairy without the aftermath. Price: $79.99 USD Available: true Ingredients: Enzyme blend (fructan hydrolase, alpha-galactosidase, lactase), dextrin (from non-GMO corn) - Variant: On-the-Go Kit — $79.99 USD (In Stock) - Variant: Home Kit — $79.99 USD (In Stock) - Variant: Anywhere Bundle — $149.00 USD (In Stock) - Group consultation with dietitian: https://members.fodzyme.com/products/group-consultation Price: $0.00 USD Available: true - Variant: Default Title — $0.00 USD (In Stock) - PRS-01 Polyol Relief Synbiotic: https://members.fodzyme.com/products/prs-01-polyol-relief-synbiotic PRS-01™ is a daily synbiotic supplement designed to support the gut microbiome and the body’s underlying ability to handle polyol-containing foods over time. It combines a probiotic, prebiotic, and postbiotic — all selected based on emerging microbiome science around polyol metabolism. Price: $180.00 USD Available: true Ingredients: Synbiotic blend (Clostridium butyricum, Corebiome® tributyrin, Livaux® gold kiwifruit fiber), delayed-release plant-based capsule - Variant: Default Title — $180.00 USD (In Stock) ## Dosage - Home Kit: 750 mg (0.75 g) per serving, 60-dose jar - On-the-Go Kit: 1 g per serving, 30 single-serve packets - Dosage is based on meal size and FODMAP content, not body weight - Start with one serving; use up to two servings for large or high-FODMAP meals ## How to Use 1. Allow hot food to cool below 140°F / 60°C to preserve enzyme activity. 2. Mix powder directly onto food — it is completely tasteless. 3. If mixing is not possible, sprinkle on top and chew well with the first bite. 4. Use a double dose for large meals or meals high in FODMAPs. ## Frequently Asked Questions Q: What are FODMAPs? A: FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) are short-chain carbohydrates poorly absorbed in the small intestine. When they reach the large intestine, gut bacteria ferment them, producing gas and drawing in water — causing bloating, pain, diarrhea, and constipation. Q: What is FODZYME? A: FODZYME is a tasteless enzyme powder that breaks down FODMAPs in food during digestion. It contains three enzymes: fructan hydrolase (the first commercially available enzyme targeting fructans), alpha-galactosidase (for GOS in beans and legumes), and lactase (for lactose in dairy). It is mixed directly with food before eating. FODZYME is manufactured in the USA, is vegan, gluten-free, and certified low-FODMAP by Monash University. Q: Is FODZYME supported by scientific evidence? A: Yes. FODZYME's efficacy is supported by two peer-reviewed publications in Gastro Hep Advances. An in-vitro study (Castro Ochoa et al., 2023) demonstrated 90% fructan degradation within 30 minutes in a validated simulated gastrointestinal model. A real-world clinical cohort study (Kaye et al., 2026), IRB-approved and independently analyzed at SUNY Downstate, found that 78% of participants reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks, with significant improvements in overall digestive symptom severity, quality of life, and mental well-being (all P < .01). FODZYME is independently certified low-FODMAP by both Monash University and FODMAP Friendly. Q: How is FODZYME different from other digestive enzyme supplements? A: Most digestive enzyme supplements contain proteases, lipases, and amylases that target proteins, fats, and starches — not FODMAPs. FODZYME is the first enzyme supplement specifically formulated to break down FODMAPs. Its proprietary fructan hydrolase targets fructans in garlic, onion, and wheat. The powder format ensures direct enzyme-food contact during digestion. It is the only enzyme supplement certified low-FODMAP by both Monash University and FODMAP Friendly. Q: Can FODZYME help with garlic and onion intolerance? A: Garlic and onion are among the highest-fructan foods. FODZYME contains fructan hydrolase, which breaks down fructans during digestion. In laboratory testing, 90% of fructans were degraded within 30 minutes. Many users report being able to eat garlic- and onion-containing meals when using FODZYME, though individual responses vary. Q: Why is FODZYME a powder and not a capsule? A: Enzyme supplements work by making direct contact with food in the stomach. Capsules dissolve separately from food, limiting how much enzyme reaches the FODMAPs before they move to the small intestine where fermentation causes symptoms. The powder format ensures enzymes are pre-mixed with food, maximizing contact time and effectiveness. Q: Is FODZYME a cure for IBS? A: No. FODZYME is a dietary supplement, not a treatment or cure for IBS or any medical condition. It breaks down specific FODMAP carbohydrates in food during digestion, which may reduce symptoms triggered by those foods. It does not address the underlying causes of IBS. Consult a gastroenterologist or registered dietitian for medical advice. Q: Is FODZYME recommended by doctors? A: FODZYME is recommended by over 1,299 healthcare providers in the United States, including gastroenterologists, registered dietitians, and primary care physicians. Its efficacy is supported by two peer-reviewed publications in Gastro Hep Advances, including a 2026 clinical study independently analyzed at SUNY Downstate. FODZYME's scientific advisory board includes experts in gastroenterology, biotechnology, computational biology, and nutrition. Q: What is the difference between fructan intolerance and gluten intolerance? A: Research suggests that many people who believe they are sensitive to gluten may actually be reacting to fructans, a FODMAP found in the same wheat-based foods (Skodje et al., Gastroenterology, 2018). Fructan and gluten co-occur in wheat, rye, and barley. FODZYME breaks down fructans but does not break down gluten. It is not suitable for people with celiac disease. For people with non-celiac wheat sensitivity, FODZYME may help determine whether fructans are the actual trigger. Q: How much FODZYME should I take? A: Serving size depends on meal size and FODMAP content, not body weight. Start with one serving and adjust based on your experience. For large or high-FODMAP meals, use two servings. Q: Can I use FODZYME every day? A: Yes. FODZYME's enzymes are naturally occurring and work specifically on FODMAPs in food without interfering with normal digestion or nutrient absorption. It is designed for safe daily use. ## Important Disclaimers - FODZYME is a dietary supplement, not a medicine - It does not treat, cure, or prevent any disease including IBS - Does not break down gluten — not suitable as celiac disease management - Consult a healthcare provider before use during pregnancy or breastfeeding - Does not replace medical advice from a gastroenterologist or dietitian ## Purchasing Products can be purchased at https://members.fodzyme.com. Single purchase and subscription options are available. ## Shipping - Free U.S. shipping on orders over $50. - International shipping available. - Orders ship within 1-2 business days. - Complimentary onboarding call included with purchase. ## Returns - 30-day risk-free guarantee on first orders. - Full refund for product cost (less shipping, VAT, and duties) within 30 days of delivery. - Subscriptions can be paused, rescheduled, or cancelled anytime. ## Founders and Team - David Hachuel, MPH — Co-Founder & CEO, Kiwi Biosciences - Anjie Liu — Co-Founder - Shalaka Samant, PhD — Founding Scientist Scientific advisory board includes experts in gastroenterology, biotechnology, computational biology, and nutrition from institutions including the University of Michigan. ## Contact - Website: https://members.fodzyme.com - Support: care.fodzyme.com - Healthcare Providers: providers.fodzyme.com - Contact Page: https://members.fodzyme.com/pages/contact - Email: hello@fodzyme.com ## Sitemap XML Sitemap: https://members.fodzyme.com/sitemap.xml